Blood test can predict clinical response to immunotherapy in metastatic NSCLC

Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations. A clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center shows that in cases where the liquid biopsy detects higher volumes of mutations, patients with cancers that have spread are more likely to see a clinical benefit at six months, as well as to survive longer without seeing their disease progress. The findings published today in Clinical Cancer Research, a journal of the American Association for Cancer Research.
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Surveillance after surgery does not improve outcomes for patients with glioblastoma

Glioblastoma is an aggressive and deadly brain cancer. Although improved treatment protocols have doubled the survival rate over the past 20 years, glioblastoma tumors usually grow back. After surgeons remove the tumor, patients typically undergo surveillance imaging within 48 hours followed by regular screenings to monitor for recurrence. However, a retrospective study from the University of Missouri School of Medicine and MU Health Care showed patients who underwent surveillance imaging after surgery did not have better outcomes than patients who did not have imaging and returned when they felt symptoms of recurrence.
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Researchers identify novel anti-aging targets

A recent study published in Nature has reported two conserved epigenetic regulators as novel anti-aging targets. The research, by scientists from Dr. Cai Shiqing’s Lab at the Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience of the Chinese Academy of Sciences (CAS), and Dr. Jiang Lubing’s team at Institut Pasteur, Shanghai of CAS, identified conserved negative regulators of healthy aging by using multiple modalities and systems, thus providing insights into how to achieve healthy aging.
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Bone or cartilage? Presence of fatty acids determines skeletal stem cell development

In the event of a bone fracture, fatty acids in the blood signal to stem cells that they have to develop into bone-forming cells. If there are no blood vessels nearby, the stem cells end up forming cartilage. The finding that specific nutrients directly influence the development of stem cells opens new avenues for stem cell research. Biomedical scientists from KU Leuven and Harvard University published these results in Nature.
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