Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations. A clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn’s Abramson Cancer Center shows that in cases where the liquid biopsy detects higher volumes of mutations, patients with cancers that have spread are more likely to see a clinical benefit at six months, as well as to survive longer without seeing their disease progress. The findings published today in Clinical Cancer Research, a journal of the American Association for Cancer Research.
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