Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it’s unclear what the other strand does, and how the two may be involved in cancer. New research from Thomas Jefferson University has revealed that both strands of some microRNA coordinate to act on the same cancer pathways, across multiple cancers, to drive aggressiveness and growth—two hallmarks of poor prognosis for cancer patients.
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