Parkinson’s disease protein structure solved inside cells using novel technique

The top contributor to familial Parkinson’s disease is mutations in leucine-rich repeat kinase 2 (LRRK2), whose large and difficult structure has finally been solved, paving the way for targeted therapies. University of California, San Diego researchers Reika Watanabe, Robert Buschauer, Jan Böhning, Martina Audagnotto in the laboratory led by Elizabeth Villa used a pioneering technique to reveal the structure of pathogenic LRRK2 in action. Watanabe will present the team’s research on Wednesday, February 19 at the 64th Annual Meeting of the Biophysical Society in San Diego, California.
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