Tumor cells are characterized by high degree of heterogeneity and among them, tumor-initiating cells (TICs), sometimes also called cancer stem-like cells, are considered as the culprits of cancer development and progression, due to their enhanced tumorigenic capacity as compared to the non-TICs within tumors. Although targeted elimination of TICs is an appealing strategy in cancer therapeutics, current understanding of TIC regulation is largely incomplete, hindering the rational designing of TIC-targeting approaches.
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