Many of the microbes that live in your gut are also found in your stool, and fecal microbiota transplants (FMTs) are being studied to determine whether they can improve health outcomes in patients with various diseases such as ulcerative colitis and Crohn’s disease. However, it is important to recognize that FMT does carry some risk such as bloodstream infections and the transmission of drug-resistant bacteria. Furthermore, FMT treatment for most microbiome-associated diseases has not been rigorously studied in humans—and any such studies would be subject to regulation by the Food and Drug Administration. In a pair of forums publishing February 12 in the journal Cell Host & Microbe, clinicians and an FDA scientist detail some areas of FMT research that could facilitate the development of safe and effective FMT therapies for patients.
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