Though scientist Richard Semon introduced the concept of the “engram” 115 years ago to posit a neural basis for memory, direct evidence for engrams has only begun to accumulate recently as sophisticated technologies and methods have become available. In a new review in Science, Professors Susumu Tonegawa of The Picower Institute for Learning and Memory at MIT and Sheena Josselyn of the Hospital for Sick Children (SickKids) and the University of Toronto describe the rapid progress they and colleagues have been making over the last dozen years in identifying, characterizing and even manipulating engrams, as well as the major outstanding questions of the field.
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