Directly after birth, the immune system completes production of a subtype of antibody-producing immune cells, B-1, that are to last for a lifetime. No more B1 cells are formed after that point. However, these cells are self-reactive—they produce not only antibodies against foreign substances, but also against the body’s own substances, and it is unclear why the immune system allows for the development of these particular cells. Now, a research team at Lund University in Sweden has found the mechanism that controls the growth of B1 cells in mice. The findings, which may lead to a deeper understanding of certain forms of cancer and autoimmune diseases, was recently published in the journal Science Immunology.
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