Drug that keeps surface receptors on cancer cells makes them more visible to immune cells

A drug that is already clinically available for the treatment of nausea and psychosis, called prochlorperazine (PCZ), inhibits the internalization of receptors on the surface of tumor cells, thereby increasing the ability of anticancer antibodies to bind to the receptors and mount more effective immune responses. PCZ enhanced the ability of anticancer antibodies to reduce tumor growth in mice, by temporarily increasing the clustering of a receptor targeted by anticancer antibodies on the surface of tumor cells. Temporary treatment of cancer patients with PCZ similarly resulted in receptor clustering on tumor cells inside of patients. The work appears March 5 in the journal Cell.
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Genetic study offers comprehensive and diverse view of recent US population history

Researchers have assembled one of the most comprehensive studies of population genetics ever conducted in the United States, bringing together large-scale genetics data from more than 32,000 participants in the National Geographic Genographic Project. This new view on the US, appearing March 5 in the American Journal of Human Genetics, reveals a remarkable degree of complexity. Beyond offering an intriguing view of the nation’s recent history, the findings also have important implications for health and medicine, the researchers say.
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Triglycerides control neurons in the reward circuit

Energy-dense food, obesity and compulsive food intake bordering addiction: The scientific literature has been pointing to connections between these for years. Scientists at the CNRS and Université de Paris have just shown for the first time how fatty nutrients act on the brain in the reward circuit. Published in Cell Metabolism on 5 March 2020, these results shed new light on the connection between food and eating disorders.
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