Researchers study whether high-potassium diets protect blood vessel function in salt-resistant adults

Dietary guidelines recommend that Americans consume less than 2,300 milligrams of sodium a day in their diet—about a teaspoon’s worth. The reality is that most people in the United States are eating far more sodium than that—an average of 3,400 milligrams a day—and putting themselves at risk of developing cardiovascular diseases like high blood pressure and heart disease.
Read More

One-two punch for cancer

Many cancer cells evade critical DNA surveillance and maintenance by increasing the export—by the Exportin-1 (XPO1) nucleo-cytoplasmic transport protein—of nearly all major tumor suppressor proteins from the nucleus. Thus, overexpression of XPO1 is often an indicator of poor prognosis in numerous malignancies.
Read More

Chimeras offer a new way to study childhood cancers in mice

In a new paper published March 5 in the journal Cell Stem Cell, researchers in Whitehead Institute Member Rudolph Jaenisch’s lab introduce a new way to model human neuroblastoma tumors in mice using chimeras—in this case, mice that have been modified to have human cells in parts of their nervous systems. “This may serve as a unique model that you can use to study the dynamic of immune cells within human tumors,” says Malkiel Cohen, a postdoc in Jaenisch’s lab and the first author of the paper.
Read More