Blood stem cells boost immunity by keeping a record of previous infections

A Franco-German research team led by Prof. Michael Sieweke, from the Center for Regenerative Therapies TU Dresden (CRTD) and the Center of Immunology of Marseille Luminy (CNRS, INSERM, Aix-Marseille University), today uncovered a surprising property of blood stem cells: not only do they ensure the continuous renewal of blood cells and contribute to the immune response triggered by an infection, but they can also remember previous infectious encounters to drive a more rapid and more efficient immune response in the future. These findings should have a significant impact on future vaccination strategies and pave the way for new treatments of an underperforming or overreacting immune system. The results of this research are published in Cell Stem Cell on March 12, 2020.
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NCAM2 protein plays a decisive role in the formation of structures for cognitive learning

The molecule NCAM2, a glycoprotein from the superfamily of immunoglobulins, is a vital factor in the formation of the cerebral cortex, neuronal morphogenesis and formation of neuronal circuits in the brain, according to new study published in the journal Cerebral Cortex. The deficit of NCAM2 causes an incorrect migration of neurons and alters the morphology, cytoskeleton and functionality of these cells in the central nervous system.
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Disaster expert outlines how first responders will tackle COVID-19

As the coronavirus pandemic continues to swell, first responders and emergency room personnel are squarely in the path of COVID-19. Against a backdrop of reports of tight supplies of personal protective equipment, the Gazette turned to Paul Biddinger, director of Massachusetts General Hospital’s Center for Disaster Medicine, vice chairman for emergency preparedness in MGH’s Emergency Medicine Department, and associate professor at Harvard Medical School, to describe the massive public health challenge facing police, fire, and emergency medical responders.
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