Doctors successfully synchronize both sides of the heart with promising new wirelessly powered, leadless pacemaker

Researchers at Texas Heart Institute (THI) and UCLA crossed a significant milestone in the development of wirelessly powered, leadless pacemakers. In an article in the Nature Research journal Scientific Reports, the team used their innovative pacing system to reveal the ability to provide synchronized biventricular pacing to a human-sized heart in a preclinical research model.
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Brain inflammation in veterans with Gulf War illness

In a new discovery, researchers at Massachusetts General Hospital (MGH) have detected widespread inflammation in the brains of veterans diagnosed with Gulf War Illness (GWI). These findings, published online in the journal Brain, Behavior, and Immunity on February 3, could serve as a guidepost for identifying and developing new therapies for people with GWI, as well as many other chronic conditions that have recently been linked to inflamed brain tissue, or neuroinflammation.
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Ceramides predict vascular brain injury and dementia

Novel blood-based biomarkers for dementia could identify disease at an early preclinical stage, serve as surrogate outcomes for clinical trials of investigational therapies and even identify future potential therapeutic targets. Unlike cerebrospinal fluid biomarkers that require a spinal tap, plasma biomarkers can be extracted from the blood, making their collection much less invasive and much more appealing for patients. In a study published in Annals of Clinical and Translational Neurology, a team led by investigators from Brigham and Women’s Hospital describes the role of plasma ceramides in dementia and Alzheimer’s disease (AD) and their potential as a blood-based biomarker.
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How early life trauma can contribute to functional neurological disorder

In individuals with functional neurological disorder (FND), the brain generally appears structurally normal on clinical MRI scans but functions incorrectly (akin to a computer software crashing), resulting in patients experiencing symptoms including limb weakness, tremor, gait abnormalities and non-epileptic seizures. In some cases, childhood maltreatment may have been a contributing factor, yet links between risk factors such as childhood abuse and brain mechanisms for the development of FND remain poorly understood. In a new study published in Molecular Psychiatry, researchers led by investigators at Massachusetts General Hospital (MGH) examined the brains of individuals who experienced early-life trauma, some with FND and others without the condition. The findings may provide a better understanding of what happens in the brains of some patients with FND, as well as those with various other trauma-related brain disorders.
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‘Quit vaping searches increased during lung-disease outbreak

E-cigarettes have been sold for more than a decade, seemingly without incident, but in the summer of 2019 serious lung injuries began appearing among some e-cigarette users—especially adolescents and young adults. By last January of 2020, the Centers for Disease Control and Prevention reported more than 2,700 hospitalizations for EVALI, or e-cigarette or vaping product use-associated lung injury, and confirmed 60 deaths in 27 states with more under investigation. The cases have now been linked primarily vaping of marijuana and additives, but before this was discovered, many people using nicotine-containing e-cigarettes became concerned.
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