Subtle decline in cognition predicts progression to Alzheimer’s pathology

Alzheimer’s disease (AD) is progressive, but slow to develop—or at least to reveal itself. In a new study, published online February 14, 2020 in the journal Biological Psychiatry, researchers at University of California San Diego School of Medicine, with colleagues elsewhere, report that early, subtle differences in cognitive performance, such as fewer words recalled on a memory test, are a sign that harmful proteins are accumulating in the brain, even if levels of those proteins do not yet qualify as dangerous.
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A good blood supply is good for memory

Memory performance and other cognitive abilities benefit from a good blood supply to the brain. This applies in particular to people affected by a condition known as “sporadic cerebral small vessel disease.” Researchers of the German Center for Neurodegenerative Diseases (DZNE) and the University Medicine Magdeburg report on this in the journal Brain. Their study suggests that blood perfusion of the so-called hippocampus could play a key role in age- and disease-related memory problems.
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