Inhibiting Nrf2 protein ubiquitination and degradation in non-small cell lung cancer

Lung cancer is the predominant cause of cancer related deaths. Within the main types of lung cancers, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), NSCLC accounts for approximately 85%, with a poor five year survival of only ~15%. Despite the significant progress in treatment options, prognosis remains poor because of the locally advanced metastatic tumors in most patients at the time of diagnosis.
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Keeping kids active despite the weather: Promoting outdoor activity all year round

Given the climate in much of Canada, cold, wet or snowy conditions are inescapable for many months of the year. And like it or not, weather and seasonality are a barrier to Canadian children engaging in physical activity. Consequently, we need to find a way to help children (as well as parents and educators) embrace the outdoors and stay active all year round.
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Cellular stress makes obese mothers have obese babies

Maternal obesity increases the risk for obesity and metabolic perturbations in their offspring, but what are the mechanisms? In a new study published March 12 in the open-access journal PLOS Biology, Sebastien Bouret of the French National Institute of Health and Medical Research (INSERM) in Lille, France, and colleagues show that a key step in the process is the triggering of stress in a complex membrane system within all cells called the endoplasmic reticulum (ER). That stress leads to critical changes in the development of the hypothalamus, a part of the brain that controls hunger, satiety, and metabolic rate.
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