ACR releases reproductive health guideline for patients with rheumatic diseases

Today, the American College of Rheumatology (ACR) published the 2020 Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. This is the first, evidence-based, clinical practice guideline related to the management of reproductive health issues for all patients with rheumatic diseases. With 131 recommendations, the guideline offers general precepts that provide a foundation for its recommendations and good practice statements.
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Video game-like intervention shows promise in improving attention of children with ADHD

A four-week randomised controlled trial of 348 children aged 8-12 years, published in journal The Lancet Digital Health, suggests that a digital intervention for paediatric attention deficit hyperactivity disorder (ADHD) might help to improve inattention with minimal adverse effects. Further research is needed to confirm the clinical meaningfulness of the observed changes, but the digital nature of the intervention could help to improve access for some patients.
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Women older than 75 may not reap death benefit from continued mammography screening

Healthy women over the age of 75 years might not benefit from continuing breast cancer screening. Researchers used data from the Medicare program to estimate the risk of breast cancer mortality under two strategies: continuing versus stopping screening in older women. They found a small mortality benefit for continuing to screen women between the ages of 70 to 74, but not those between 75 to 84. Findings from this population-based observational study are published in Annals of Internal Medicine.
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Too much of a good thing may lead to too much of a liver as well

All life is challenged by oxidants—reactive molecules or compounds that remove electrons from other molecules—often with adverse effect, commonly referred to as oxidative stress. Consequently, all organisms have evolved specialized antioxidant defenses. In humans and other multicellular animals, that defense depends upon a protein called NRF2 and its inhibitor, KEAP1.
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