Recent advances in the development of cancer therapies have increased long-term survival and prognosis. However, the increased burden and prevalence of harmful side effects, including cardiomyopathy, have emerged alongside those therapeutic benefits. In particular, there have been increases in cancer therapy-induced cardiomyopathy (CCM)—a heart condition which may compromise a patient’s quality of life and long-term prognosis after the cancer has been treated. And while certain clinical risk factors for CCM are known, the factors that contribute to an individual’s susceptibility remain a mystery. A team of investigators from Brigham and Women’s Hospital and Harvard Medical School finds that genetics may be at play and elucidates rare genetic variants which may influence risk for developing CCM. Results are published in Circulation.
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